Building molecules
分子をつなぐ。
Making bonds by breaking bonds: An unconventional approach to making molecules
Making bonds by breaking bonds: An unconventional approach to making molecules
Nakahara, H.; Isshiki, R.; Kubo, M; Iizumi, K.: Muto, K.; Yamaguchi, J.
Chem. 2024
Nakahara, H.; Isshiki, R.; Kubo, M; Iizumi, K.: Muto, K.; Yamaguchi, J.
Chem. 2024
We attended the 11th Keio Young Organic Chemists Symposium, which was held on May 11th.
We attended the 11th Keio Young Organic Chemists Symposium, which was held on May 11th.
Yamaguchi Group
Latest research achievements
Latest Activity
合成化学を究める
Developing new synthetic methodologies requires a broad range of scientific knowledge, creative thinking, and a systematic research approach. In our laboratory, many members individually pursue entirely different approaches to deeply understand the fundamental mechanisms and principles of chemical reactions. When these individual efforts connect and converge, new methodologies emerge.
Developing new reactions requires the creation of novel catalysts that can lower activation energies to previously unattainable levels. Initially, these ideas may seem like mere speculation, but through trial and error, valuable insights can be gained, allowing for the rational design of catalysts. Although catalyst development is fraught with challenges, the creation of a new catalyst can bring innovative methodologies and the synthesis of new molecules within reach.
With new methodologies and catalysts, we can create novel molecules. Total synthesis research, which efficiently synthesizes bioactive compounds, is also crucial for showcasing these advancements. Additionally, we provide novel frameworks that aid chemists in molecular craftsmanship.
We collaborate to create drug-related molecules and biomarkers. We also take on the challenge of creating molecules that require protein structural analysis and other structurally interesting organic molecules.
A molecule—which is the smallest fundamental unit of matter that exhibits the properties of the substance—can be structurally combined in an infinite number of ways. Building a multitude of such molecules while exploring new chemical space is not only “fun” but also opens up “new possibilities” to serve the chemical, as well as the global, community. The discipline that can realize the creation of new molecules is synthetic chemistry. In order to contribute to the continued development of synthetic chemistry, our research goals are three-fold: building molecules/destroying molecules/creating game-changing molecules. To tackle these fundamental pursuits in synthetic chemistry, we aim to become masters in the art of molecular construction by using unique synthetic strategies and catalyst designs.
人類が最小の機能分子「分子」をつなぐ方法、つまり分子構築法を研究し始めてからおよそ200年。長いように思えますが、文学や法などの研究はもちろ
分子をつなぐ
分子をつくる以上、結合の切断と形成は表裏一体です。自在な分子構築を達成するためは望みの結合を切断することからはじまります。安定な炭素—炭素
分子をぶっ壊す。
開発した触媒は既に機能が約束された分子群、例えば医薬品候補分子や天然有機化合物の合成に利用します。それだけでなく未知の機能分子の創製やその機
革新的な分子をつくる。
我々の最新の研究成果を個別に紹介します。
Selective C−N Bond Cleavage in Unstrained Pyrrolidines Enabled by Lewis Acid and Photoredox CatalysisKazuhiro Aida,# Marina Hirao,# Tsuyoshi Saitoh,
2H-Thiazolotriazole: Synthesis, Functionalization, and Application in Scaffold-HoppingMiyazaki, R.; Takada, F.; Kikuchi, T.; Oguro, Y.; Kamata, M.
Versatile Deacylative Cross-coupling of Aromatic KetonesNakahara, H.; Isshiki, R.; Kubo, M; Iizumi, K.: Muto, K.; Yamaguchi, J.Chem. 2024 online n
Deoxygenative Functionalizations of Aromatic Dicarbonyls and AldehydesSakihara, M.; Shimoyama, S.; Kurosawa, M. B. Yamaguchi, J.Bull. Chem. Soc. J