Our research findings have been featured in a university press release and published online.
Accelerating Drug Discovery through One-Step Benzene Ring Conversion
— Transforming aromatic ketones into diverse heterocycles in a single step —
Highlights
• We have developed a new reaction that enables the one-step replacement of an aromatic ring with a heteroaromatic ring, a key transformation in drug discovery.
• By re-examining a classical reaction and overturning the long-held belief that this transformation “does not proceed,” we achieved in one step what previously required multiple steps.
• The reaction is applicable to complex molecules derived from pharmaceuticals and natural products, providing high yields under mild conditions.
• This technology is expected to serve as a foundation for accelerating structural diversification and property optimization of drug molecules, contributing to the creation of new medicines.