Making bonds by breaking bonds: An unconventional approach to making molecules
Making bonds by breaking bonds: An unconventional approach to making molecules
Kubo, M.; Yamaguchi, J.
Acc. Chem. Res. 2024, ASAP
Kubo, M.; Yamaguchi, J.
Acc. Chem. Res. 2024, ASAP
We attended the 11th Keio Young Organic Chemists Symposium, which was held on May 11th.
We attended the 11th Keio Young Organic Chemists Symposium, which was held on May 11th.
Yamaguchi Group
Latest research achievements
Latest Activity
合成化学を究める
Developing new synthetic methodologies requires a broad range of scientific knowledge, creative thinking, and a systematic research approach. In our laboratory, many members individually pursue entirely different approaches to deeply understand the fundamental mechanisms and principles of chemical reactions. When these individual efforts connect and converge, new methodologies emerge.
Developing new reactions requires the creation of novel catalysts that can lower activation energies to previously unattainable levels. Initially, these ideas may seem like mere speculation, but through trial and error, valuable insights can be gained, allowing for the rational design of catalysts. Although catalyst development is fraught with challenges, the creation of a new catalyst can bring innovative methodologies and the synthesis of new molecules within reach.
With new methodologies and catalysts, we can create novel molecules. Total synthesis research, which efficiently synthesizes bioactive compounds, is also crucial for showcasing these advancements. Additionally, we provide novel frameworks that aid chemists in molecular craftsmanship.
We collaborate to create drug-related molecules and biomarkers. We also take on the challenge of creating molecules that require protein structural analysis and other structurally interesting organic molecules.
A molecule—which is the smallest fundamental unit of matter that exhibits the properties of the substance—can be structurally combined in an infinite number of ways. Building a multitude of such molecules while exploring new chemical space is not only “fun” but also opens up “new possibilities” to serve the chemical, as well as the global, community. The discipline that can realize the creation of new molecules is synthetic chemistry. In order to contribute to the continued development of synthetic chemistry, our research goals are three-fold: building molecules/destroying molecules/creating game-changing molecules. To tackle these fundamental pursuits in synthetic chemistry, we aim to become masters in the art of molecular construction by using unique synthetic strategies and catalyst designs.
人类最小的功能单元「分子」的结合，即分子构建的产生和发展历史已经有200年了。虽然这一研究也历经百年，但是相比起文学、法学以及科学中的机械等
分子的结合
合成一个分子的话，键的切断和形成其实是矛盾统一的。实现自由自在的分子构建，也要从想要切断的键开始入手。稳定的碳-碳键的切断伴随新分子化学键的
分子的切断
我们利用开发的催化剂，开发合成一定功能的分子库群，应用到医药品候补分子或天然有机化合物等合成中。除此之外，开发打造未知的功能分子，以及挑战揭
革新分子的打造
我々の最新の研究成果を個別に紹介します。
Eito Moriya, Kei Muto, and Junichiro Yamaguchi*ACS Catal. 2024, 14, 10412–10417.DOI: 10.1021/acscatal.4c02707This manuscript describes the devel
Divergent Transformations of Aromatic Esters: Decarbonylative Coupling, Ester Dance, Aryl Exchange, and Deoxygenative CouplingKubo, M.; Yamaguchi, J
Harnessing Zirconocene (III) for Photoinduced Carbon Radical GenerationOta, E.; Aida, K.; Yamaguchi, J.Chem. Lett. 2024, Accepted Manuscript
Sakihara, M. Kurosawa, M. B.; Watanabe, M.; Shimoyama, S.; Yamaguchi, J.J. Org. CHem. 2024, ASAPDOI 10.1021/acs.joc.4c00831Direct transforma