70. C–H Arylation and Alkenylation of Imidazoles by Nickel Catalysis: Solvent-accelerated Imidazole C–H Activation

Muto, K.; Hatakeyama, T.; Yamaguchi, J.; Itami, K.
Chem. Sci. 20156, 6792–6798.
DOI 10.1039/C5SC02942B
Detail イミダゾール類のアリール化

2016-09-19_18-08-21 2016-05-14_11-25-00

69. Decarbonylative organoboron cross-coupling of esters by nickel catalysis

Muto K.; Yamaguchi, J.*; Musaev, D.G.; Itami, K.
Nature. Commun20156, 7508.
DOI 10.1038/ncomms8508
HighlightsSience Daily, Phys. Org, Nature Communnications Highlights Article

2016-09-19_18-07-29 2016-05-14_11-26-05

68. C-H Activation Generates Period-Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock

Oshima, T.; Yamanaka, I.; Kumar, A.; Yamaguchi, J.; Nishiwaki Ohkawa, T.; Muto, K.; Kawamura, R.; Hirota, T.; Yagita, K.; Irle, S.; Kay, S. A.; Yoshimura, T.; Itami, K.
Angew. Chem., Int. Ed. 201554, 7193.
DOI 10.1002/anie.201502942
Detail 触媒で体内時計のリズムを変える
Highlights Chunichi Shimbun, Yahoo! News, Zaikei Shimbun, Monolist, Alpha Gelileo JP,EurekAlert! JP, Kagaku, ResearchSEA, Alpha Galileo, EurekAlert!, Biology News Net, ScienceNewsline, Science Daily, Medical News Today, Press News Org, Deep Stuff, News Medical, Health Medicine Net, Bio Spectrum, Chemisch2Weekblad, Lab Roots, EN-CPhI.CN, Terra Daily, Open Science  World, Sleep Review, Asian Scientist. Selected as Cover of the journal.

2016-09-19_18-02-07 2016-05-14_11-26-24

67. Synthesis and Characterization of Hexaarylbenzenes with Five or Six Different Substituents Enabled by Programmed Synthesis

Suzuki, S.; Segawa, Y.; Itami, K.; Yamaguchi, J.
Nature Chem. 20157, 227–233.
DOI 10.1038/nchem.2174
Highlights Toyo Keizai, Yahoo! Japan News, Chunichi Shimbun, Asahi Shimbun, Nikkei Shimbun, Nifty News, Nokoniko News, Infoseek News, Nikkei Press News, Science Portal, Japanese Research, JPubb, Mynabi News, Zaikei Shimbun, The Huffington Post, Livedoor News, Bioimpact, Nikkei Biotech, Biglobe News, Ascii, EurekAlert!, ResearchSEA, Science Newsline, Phys.Org, Chemicals Technology, Chemistry News, Health Medicine Network, Science Daily, Technobahn, Innovation Reports, Chemistry 2011, RevoScience, Asian Scientist, Kagaku Shimbun, Alpha Galileo, Chemical & Engineering News, Synfacts.

2016-09-19_18-01-12 2016-05-14_11-26-52

66. Concise Syntheses of Dictyodendrins A and F by a Sequential C–H Functionalization Strategy

Yamaguchi, A. D.; Chepiga, K. M.; Yamaguchi, J.; Itami, K.; Davies, H. M. L.
J. Am. Chem. Soc. 2015137, 644–647.
DOI 10.1021/ja512059d
Highlights EurekAlerts!, Phys.Org., ResearchSEA, Science Newsline, Science Daily, Breaking New, Health Medicine Network, Bright Surf, Sci Casts, Medical News Today, Emory News Center, Society for Neuroscience. 

2016-09-19_17-59-58 2016-05-14_11-27-05

65. Synthesis, Affinity and Structure Activity Relationships of Novel, Selective and Dual Targeting CCR2 and CCR5 Receptor Antagonists

Junker, A.; Kokornaczyk, A. K.; Frehland, B.; Schepmann, D.; Yamaguchi, J.; Itami, K.; Faust, A.; Hermann, S. Wagner, S.; Kopka, K.; Schäfers, M.; Koch, M.; Weiss, C.; Zweemer, A. J. M. Heitman, L. H.; Wünsch, B.
Org. Biomol. Chem. 201513, 2407–2422.
DOI 10.1039/C4OB02397H

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64. Ni-Catalyzed -Arylation of Esters and Amides with Phenol Derivatives

Koch, E.; Takise, R.; Studer, A.; Yamaguchi, J.; Itami, K.
Chem. Commun. 201551, 855–857.
DOI 10.1039/C4CC08426H
Highlights Top 25 most downloaded articles (Oct-Dec 2014).

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63. Stereodivergent Synthesis of Arylcyclopropylamines by Sequential C–H Borylation and Suzuki–Miyaura Couplingses

Miyamura, S.; Araki, M.; Suzuki, T.; Yamaguchi, J.; Itami, K.
Angew. Chem., Int. Ed. 201554, 846–851
DOI 10.1002/anie.201409186

2016-09-19_17-56-16 2016-05-14_11-34-40

62. Key Mechanistic Features of the Ni-catalyzed C–H/C-O Biaryl Coupling with Azoles and NaphthalenylPivalates

Xu, H. Muto, K.; Yamaguchi, J.; Itami, K.; Musaev, D.G.
J. Am. Chem. Soc. 2014136, 14834–14844.
DOI 10.1021/ja5071174

Details Highlights EurekAlerts!, Phys.Org., Science Codex, Science Newsline, Science Daily, Emory University eScience Commons, Bright Surf, Laboratory Equipment, Web Newswire, Medical News, Today, Emory News Center, Jersey Tribune, Science Seeker, News Locker, USA News, News Nom, Bio Portfolio, Toronto Telegraph, Technobahn, The Daily Purrs, Chemistry2011. 

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61. ß-Selective C–H Arylation of Pyrroles Leading to Concise Syntheses of Lamellarins C and I

Ueda, K.; Amaike, K.; Maceiczyk, R. M; Itami, K.; Yamaguchi, J.
J. Am. Chem. Soc. 2014136, 13226–13232.
DOI 10.1021/ja508449y
HighlightsMost Read Article (September­–October, 2014) 

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60. Regioselective Allylic C–H Oxidation of Terminal Alkenes with Pd/sulfoxide-oxazoline Catalyst

Kondo, H.; Yu, F.; Yamaguchi, J.; Liu ,G.; Itami, K.
Org. Lett. 2014, 16, 4212–4215.
DOI 10.1021/ol5019135

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59. Ni-Catalyzed α-Arylation of Ketones with Phenol Derivatives

Takise, R.; Muto, K.; Yamaguchi, J.; J. Itami K.
Angew. Chem., Int. Ed. 201453, 6791–6794.
DOI 10.1002/anie.201403823
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2016-09-19_17-49-32 2016-07-19_17-38-31

58. 2,4- and 2,5-Disubstituted Arylthiazoles: Rapid Synthesis by C–H Coupling and Biological Evaluation

Lohrey, L.; Uehara, T. N.; Tani, S.; Yamaguchi, J.; Humpf, H.-U.; Itami, K.
Eur. J. Org. Chem. 2014, 3387–3394.
DOI 10.1002/ejoc.201402129

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57. Manganese-Catalyzed Intermolecular C–H/C–H Coupling of Carbonyls and Heteroarenes

Hattori, K.; Ziadi, A.; Itami, K.; Yamaguchi, J. Chem. Comm. 201450, 4105–4107.
DOI 10.1039/C4CC01376J
HighlightsMost Read Article (March, 2014)


56. Late-Stage C–H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues

Sekizawa, H.; Amaike, K.; Itoh, Y.; Suzuki, T.; Itami, K.; Yamaguchi, J.
ACS. Med. Chem. Lett. 2014, 582–586.
DOI 10.1021/ml500024s

Highlights Most Read Article (March, 2014)

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55. Diverse Modification of the 4-Methylphenyl Moiety of TAK-779 by Late-Stage Suzuki-Miyaura Cross-Coupling

Junker, A.; Schepmann, D.; Yamaguchi, J.; Itami, K. Faust, A.; Kopka, K.; Wagner, S.; Wünsch, B.
Org. Biomol. Chem. 201412, 177–186.
DOI 10.1039/C3OB41873A

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54. Programmed Synthesis of Arylthiazoles through Sequential C-H Couplings

Tani, S.; Uehara, T. N.; Yamaguchi, J.; Itami, K.
Chem. Sci. 2014, 5, 123–135.
DOI 10.1039/C3SC52199K
Highlights Synfacts. Most Read Articles in October in 2013, 

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