博士論文

高活性な植物概日時計長周期化分子の創製

Synthesis of potent plant circadian clock modulators

研究業績

101. Dibenzofuran Synthesis: Decarbonylative Intramolecular C‐H Arylation of Aromatic Esters

Okita, T.; Komatsuda, M.; Saito, A. N,; Hisada, T.; Takahara, T. T.; Nakayama, K. P.; Isshiki, R.; Takise, R.; Muto, K.; Yamaguchi, J.
Asian J. Org. Chem. 2018, 7, 1358-1361.
DOI 10.1002/ajoc.201800207
Highlights Invitation to Contribute to a Special Issue: C–H Activation
Highlights the top 10% most downloaded papers between January 2018 and December 2019

106.Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock

Uehara, T. N.; Mizutani, Y.; Kuwata, K.; Hirota, T.; Sato, A.; Mizoi, J.; Takao, S.; Matsuo, H.; Suzuki, T.; Ito, S.; Saito, A. N.; Nishiwaki Ohkawa, T.; Yamaguchi-Shinozaki, K.; Yoshimura, T.; Kay, S. A.; Itami, K.; Kinoshita, T.; Yamaguchi, J.; Nakamichi, N.
Proc Natl Acad Sci USA 2019, 116, 11528-11536.
DOI 10.1073/pnas.1903357116

107.Structure–function study of a novel inhibitor of the casein kinase 1 family in Arabidopsis thaliana

Saito, A. N.; Matsuo, H.; Kuwata, K.; Ono, A.: Kinoshita, T.; Yamaguchi, J.; Nakamichi, N.
Plant Direct, 2019, 3, e00172.
DOI 10.1002/pld3.172
bioRxiv 2019
DOI 10.1101/642884

108. Pd-Catalyzed Denitrative Intramolecular C–H Arylation

Asahara, K. K.; Okita, T.; Saito, A. N. Muto, K.; Nakao, Y.; Yamaguchi, J.
Org. Lett. 2019, 21, 4721-4724.
DOI 10.1021/acs.orglett.9b01593
Highlights Most Read Article (July, 2019)

130. Phosphorylation of RNA Polymerase II by CDKC;2 Maintains the Arabidopsis Circadian Clock Period

Uehara, T. N.; Nonoyama, T.; Taki, K.; Kuwata, K.; Sato, A.; Fujimoto, K. J.; Hirota, T.; Matsuo, H.; Maeda, A. E.; Ono, A.; Takahara, T. T.; Tsutsui, H.; Suzuki, T.; Yanai, T.; Kay, S. A.; Itami, K.; Kinoshita, T.; Yamaguchi, J.; Nakamichi, N.
Plant Cell Physiol. 2022, 63, 450–462.
DOI 10.1093/pcp/pcac011

138. Chemical biology to dissect molecular mechanisms underlying plant circadian clocks

Nakamichi, N. Yamaguchi, J.; Sato, A.; Fujimoto, K. J. Ota, E.
New Phytologist 2022, 235, 1336–1343.
DOI 10.1111/nph.18298

142. Structure-Function Study of a Novel Inhibitor of Cyclin-Dependent Kinase C in Arabidopsis

Saito, A. N.; Maeda, A. E.; Takahara, T. T.; Matsuo, H.; Nishina, M.; Ono, A.; Shiratake, K.; Notaguchi, M.; Yanai, T.; Kinoshita, T.; Ota, E.; Fujimoto, K. J.; Yamaguchi, J.; Nakamichi, N.
Plant Cell Physiol 2022, 63, 1720–1728,
DOI 10.1093/pcp/pcac127

148. Development of Plant Circadian Clock Modulators

Saito, A. N.; Ota, E.; Nakamichi, N.; Yamaguchi, J.
J. Synth. Org. Chem. Jpn 2023, 81, 718–730.
DOI 10.5059/yukigoseikyokaishi.81.718

コメント

植物時計ケミカルバイオロジー研究の初期メンバー。名古屋で発見した化合物の高活性体を発見、自身の名前の由来となるAMI-331を研究用試薬としてこの世に出す。手先が器用で多くの反応開発や化合物の合成にも携わった。最終的に２つの概日時計長周期化作用をもつ化合物を見出した。

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