Sakihara, M.; Shimoyama, S.; Kurosawa, M. B. Yamaguchi, J.
Bull. Chem. Soc. Jpn. 2024, 97, uoae078.
DOI 10.1093/bulcsj/uoae078
In this study, we developed a method to synthesize deoxygenative functionalized products by reacting aromatic dicarbonyls with DBU, TMSOTf, diphenylphosphine oxide, and a range of nucleophiles. Moreover, we demonstrated that sequential application of phospha-Brook rearrangement and benzylic substitution conditions to aromatic aldehydes affords the deoxygenative functionalized products effectively. With highly nucleophilic reagents, it was possible to proceed with the deoxygenative functionalization without TMSOTf.
